Base de dados : HANSEN Pesquisa : IMUNIDADE NATURAL [Descritor de assunto] Referências encontradas : 23 [refinar] Mostrando: 1 .. 20   no formato [Detalhado]

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Id: 22674 Autor: Bleharski, Joshua R; Li, Huiying; Meinken, Cristoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Título: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Fonte: s.l; s.n; 2003. 4 p. . Resumo: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descritores: Algoritmos Análise por Conglomerados Contagem de Colônia Microbiana Citocinas/GE/ME Perfilação da Expressão Gênica/* Regulação da Expressão Gênica/* Genes de Imunoglobulinas Imunidade Celular Imunidade Natural Hanseníase Virchowiana/*CL/*GE/IM/PP Hanseníase Tuberculóide/*CL/*GE/IM/PP Macrófagos Alveolares/MI Glicoproteínas de Membrana/IM Mycobacterium tuberculosis/GD/IM Análise de Sequência com Séries de Oligonucleotídeos Reação em Cadeia da Polimerase Análise de Componente Principal Receptores da Superfície Celular/IM Receptores Imunológicos/GE/ME Limites: Humano Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Regulação para Cima Localização: BR191.1; 09174/s

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Id: 18986 Autor: Krutzik, Stephan R; Ochoa, Maria Teresa; Sieling, Peter A; Uematsu, Satoshi; Ng, Yolanda W; Legaspi, Annaliza; Liu, Philip T; Cole, Stewart T; Godowski, Paul J; Maeda, Yumi; Sarno, Euzenir N; Norgard, Michael V; Brennan, Patrick J; Akira, Shizuo; Rea, Thomas H; Modlin, Robert L Título: Activation and regulation of toll-like receptors 2 and 1 in human leprosy ..- Fonte: s.l; s.n; 2003. 8 p. ilus, graf. Resumo: The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cell activation by killed M. leprae, indicating the presence of triacylated lipoproteins. A genome-wide scan of M. leprae detected 31 putative lipoproteins. Synthetic lipopeptides representing the 19-kD and 33-kD lipoproteins activated both monocytes and dendritic cells. Activation was enhanced by type-1 cytokines and inhibited by type-2 cytokines. In addition, interferon (IFN)-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression. TLR2 and TLR1 were more strongly expressed in lesions from the localized tuberculoid form (T-lep) as compared with the disseminated lepromatous form (L-lep) of the disease. These data provide evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens. (AU). Descritores: CITOCINAS/fisiol HANSENIASE/imunol IMUNIDADE NATURAL LIPOPROTEINAS/anal GLICOPROTEINAS DE MEMBRANA/anal GLICOPROTEINAS DE MEMBRANA/fisiol RECEPTORES DA SUPERFICIE CELULAR/anal RECEPTORES DA SUPERFICIE CELULAR/fisiol Limites: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09113/s

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Id: 18953 Autor: Bochud, Pierre-Yves; Hawn, Thomas R; Aderem, Alan Título: Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling ..- Fonte: s.l; s.n; 2003. 4 p. graf. Resumo: Toll-like receptors (TLRs) are key mediators of the innate immune response to microbial pathogens. We investigated the role of TLRs in the recognition of Mycobacterium leprae and the significance of TLR2Arg(677)Trp, a recently discovered human polymorphism that is associated with lepromatous leprosy. In mice, TNF-alpha production in response to M. leprae was essentially absent in TLR2-deficient macrophages. Similarly, human TLR2 mediated M. leprae-dependent activation of NF-kappaB in transfected Chinese hamster ovary and human embryonic kidney 293 cells, with enhancement of this signaling in the presence of CD14. In contrast, activation of NF-kappaB by human TLR2Arg(677)Trp was abolished in response to M. leprae and Mycobacterium tuberculosis. The impaired function of this TLR2 variant provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy and may have important implications for understanding the pathogenesis of other mycobacterial infections. (AU). Descritores: CELULAS CHO LINHAGEM CELULAR IMUNIDADE NATURAL/genet ARGININA/genet HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol GLICOPROTEINAS DE MEMBRANA/defic GLICOPROTEINAS DE MEMBRANA/genet GLICOPROTEINAS DE MEMBRANA/fisiol CAMUNDONGOS ENDOGÂMICOS C57BL CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM TUBERCULOSIS/imunol POLIMORFISMO DE UM UNICO NUCLEOTIDIO/imunol TRANSDUCAO DE SINAL/imunol TRIPTOFANO/genet RECEPTORES DA SUPERFICIE CELULAR/defic RECEPTORES DA SUPERFICIE CELULAR/genet RECEPTORES DA SUPERFICIE CELULAR/fisiol Limites: HUMANO ANIMAL HAMSTERS CAMUNDONGOS SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09085/s

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Id: 18580 Autor: Oliveira, Rosane B; Ochoa, Maria T; Sieling, Peter A; Rea, Thomas H; Rambukkana, Anura; Sarno, Euzenir N; Modlin, Robert L Título: Expression of toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy ..- Fonte: s.l; s.n; 2003. 7 p. ilus, graf. Resumo: Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity. We investigated the possibility that human Schwann cells are susceptible to cell death through the activation of Toll-like receptor 2 (TLR2), a pattern recognition receptor of the innate immune system. TLR2 was detected on the surface of human Schwann cell line ST88-14 and on cultured primary human Schwann cells. Activation of the human Schwann cell line and primary human Schwann cell cultures with a TLR2 agonist, a synthetic lipopeptide comprising the N-terminal portion of the putative Mycobacterium leprae 19-kDa lipoprotein, triggered an increase in the number of apoptotic cells. The lipopeptide-induced apoptosis of Schwann cells could be blocked by an anti-TLR2 monoclonal antibody. Schwann cells in skin lesions from leprosy patients were found to express TLR2. It was possible to identify in the lesions Schwann cells that had undergone apoptosis in vivo. The ability of M. leprae ligands to induce the apoptosis of Schwann cells through TLR2 provides a mechanism by which activation of the innate immune response contributes to nerve injury in leprosy. (AU). Descritores: APOPTOSE CELULAS CULTIVADAS DANO DO DNA IMUNIDADE NATURAL HANSENIASE/imunol HANSENIASE/patol LIPOPROTEINAS/fisiol CELULAS DE SCHWANN/patol GLICOPROTEINAS DE MEMBRANA/anal GLICOPROTEINAS DE MEMBRANA/fisiol RECEPTORES DA SUPERFICIE CELULAR/anal RECEPTORES DA SUPERFICIE CELULAR/fisiol Limites: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S Meio Eletrônico: - . Localização: BR191.1; 09028/s

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Id: 18504 Autor: Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L Título: Use of genetic profiling in leprosy to discriminate clinical forms of the disease ..- Fonte: s.l; s.n; Sep. 2003. 4 p. graf. Resumo: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU). Descritores: HANSENIASE VIRCHOWIANA/clas HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/fisiopatol HANSENIASE TUBERCULOIDE/clas HANSENIASE TUBERCULOIDE/genet HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/fisiopatol CITOCINAS/genet CITOCINAS/metab PERFILACAO DA EXPRESSÃO GÊNICA ANALISE POR CONGLOMERADOS CONTAGEM DE COLÔNIA MICROBIANA REGULACAO DA EXPRESSÃO GÊNICA IMUNIDADE CELULAR IMUNIDADE NATURAL MACROFAGOS ALVEOLARES/microbiol GLICOPROTEINAS DE MEMBRANA/imunol MYCOBACTERIUM TUBERCULOSIS/cresc MYCOBACTERIUM TUBERCULOSIS/imunol REACAO EM CADEIA DA POLIMERASE RECEPTORES IMUNOLOGICOS/genet RECEPTORES IMUNOLOGICOS/metab RECEPTORES DA SUPERFICIE CELULAR/imunol - REGULACAO PARA CIMA  Análise de Componente Principal  ALGORITMOS  GENES DE IMUNOGLOBULINAS  ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS Limites: SUPPORT, NON-U.S. GOV'T HUMANO SUPPORT, U.S. GOV'T, P.H.S. Meio Eletrônico: - . Localização: BR191.1; 09142/s; BR191.1; 09145/s

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Id: 18467 Autor: Kang, Tae Jin; Lee, Seong-Beom; Chae, Gue-Tae Título: A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy ..- Fonte: s.l; s.n; Oct. 2002. 7 p. graf. Resumo: Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections, and the mutations in the TLR2 have been shown to confer the susceptibility to infection with mycobacteria. We previously reported the detection of TLR2 Arg677Trp mutation in lepromatous leprosy. Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative agent of leprosy, were investigated. Upon stimulation with MLL, monocytes produced TNF-alpha and Interleukin-12 (IL-12), which play a role in the innate immune response to infection. Anti-TLR2 mAb blocked greater than 50 per cent of the MLL-induced production of IL-12. We also performed the functional study on TLR2 by measurement of IL-12 production in serum and monocytes from leprosy patients with TLR2 mutation (Arg677Trp). The monocytes obtained from patients with the TLR2 mutation, in comparison to the wild-type TLR2, is significantly less responsive to MLL. It was also confirmed that patients with TLR2 mutation showed significantly lower serum levels of IL-12, in comparing with TLR2 wild-type. Our results reveal that innate immune response of monocytes against M. lepraeis mediated by TLR2, and suggest that the mutation in the intracellular domain of TLR2 gene is associated with IL-12 production in lepromatous leprosy. (AU). Descritores: SEQUÊNCIA DE AMINOACIDOS SEQUÊNCIA DE BASES ESTUDOS DE CASOS E CONTROLES DNA COMPLEMENTAR/genet IMUNIDADE NATURAL INTERLEUCINA-12/bios HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol GLICOPROTEINAS DE MEMBRANA/quim GLICOPROTEINAS DE MEMBRANA/genet MONOCITOS/imunol MYCOBACTERIUM LEPRAE/imunol MUTACAO PUNTUAL POLIMORFISMO (GENETICA) ESTRUTURA TERCIARIA DE PROTEINA RECEPTORES DA SUPERFICIE CELULAR/quim RECEPTORES DA SUPERFICIE CELULAR/genet FATOR DE NECROSE TUMORAL/bios Limites: HUMANO SUPPORT, NON-U.S. GOV'T HUMANO IN VITRO Meio Eletrônico: - . Localização: BR191.1; 09004/s

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Id: 18344 Autor: Alcaïs, A; Sanchez, F. O; Thuc, N. V; Lap, V. D; Oberti, J; Lagrange, P. H; Schurr, E; Abel, L Título: Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy ..- Fonte: s.l; s.n; 2000. 7 p. tab, graf. Resumo: The Mitsuda test, which measures the specific immune response against intradermally injected lepromin, has a high prognostic value for susceptibility or resistance to the lepromatous form of leprosy. A sib-pair linkage analysis between the Mitsuda response and the NRAMP1 gene was done among 20 nuclear families with leprosy (totaling 118 sibs) from Ho Chi Minh City, Vietnam. All family subjects were genotyped for several intragenic and flanking NRAMP1 markers, leading to the definition of a fully informative NRAMP1 haplotype. Significant linkage was observed between NRAMP1 and Mitsuda reaction when considered either as a quantitative (P<.002) or as a categorical (P=.001) trait. Separate analyses among healthy and affected sibs showed evidence for linkage in both subsamples, indicating that linkage between the Mitsuda reaction and NRAMP1 is independent of leprosy status. These results support the view that NRAMP1 plays a regulatory role for the development of acquired antimycobacterial immune responses as determined by in vivo Mitsuda test reaction. (AU). Descritores: HANSENIASE/imunol ANTIGENO DE MITSUDA/imunol HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol PELE/imunol VIETNA GRANULOMA CHINA/etnol - HAPLOTIPOS  IMUNIDADE NATURAL  INJECOES INTRADERMICAS  LINHAGEM  NUCLEO FAMILIAR  FENOTIPO  LINFOCITOS T AUXILIADORES-INDUTORES Limites: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Localização: BR191.1; 08991/s

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Id: 18269 Autor: Kirchheimer, W. F; Sanchez, R. M Título: Intraspecies differences of resistance against leprosy in nine-banded armadillos ..- Fonte: s.l; s.n; oct. 1981. 6 p. tab. Resumo: Infection of nine-banded armadillos with decreasing doses of armadillo-passaged leprosy bacilli show that most individuals of this species are susceptible and only about 20 percent are resistant regardless of the size of the infecting bacterial dose. It is pointed out that the intraspecies distribution of resistance to leprosy in human beings and in nine-banded armadillos differs because most individuals of the former species are resistant. Attention is drawn to the possibility that the results of anti-leprosy vaccination in armadillos might not apply to vaccination of human beings because the differences in distribution of resistant individuals might also reflect different mechanisms of susceptibility in the two species.(AU). Descritores: IMUNIDADE NATURAL HANSENIASE/imunol TATUS/imunol ESPECIFICIDADE DE ESPECIES XENARTROS/imunol Limites: ANIMAL MASCULINO FEMININO Meio Eletrônico: - . Localização: BR191.1; 00326/s

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Id: 18249 Autor: Stach, Jean-Louis; Delgado, Georgette; Strobel, Michel; Millan, Jacques; Lagrange, Philippe H Título: Preliminary evidence of natural resistance to Mycobacterium bovis (BCG) in lepromatous leprosy ..- Fonte: s.l; s.n; jun. 1984. 7 p. tab, graf. Resumo: An assay system has been developed based on radiometric quantification of 3H uracil incorporation into viable BCG in the absence or presence of blood monocytes in cultures from untreated lepromatous (LL) or tuberculoid (TT) leprosy patients. 3H Uracil incorporation into BCG was inhibited when the bacilli were cultivated in the presence of blood-derived macrophages in culture for four days, and that inhibition was always greater with macrophages harvested from LL patients compared to TT patients. The reasons for such an observed difference in humans are discussed according to our knowledge obtained in murine models of mycobacterial infections.(AU). Descritores: IMUNIDADE NATURAL HANSENIASE/imunol MACROFAGOS/imunol MYCOBACTERIUM BOVIS/imunol Limites: HUMANO ADULTO MEIA-IDADE Meio Eletrônico: - . Localização: BR191.1; 01554/s

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Id: 17762 Autor: Convit, Jacinto Título: Indigenous leprosy in the armadillo Dasypus novemcinctus ..- Fonte: s.l; s.n; dec. 1978. 3 p. . Resumo: The publication of the unusual. Descritores: XENARTROS/imunol IMUNIDADE NATURAL HANSENIASE/imunol - MEXICO  ESTADOS UNIDOS Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1

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Id: 17761 Autor: Convit, Jacinto Título: Indigenous leprosy in the armadillo Dasypus novemcinctus ..- Fonte: s.l; s.n; dec. 1978. 3 p. . Resumo: The publication of the unusual. Descritores: XENARTROS/imunol IMUNIDADE NATURAL HANSENIASE/imunol - MEXICO  ESTADOS UNIDOS Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1

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Id: 17760 Autor: Convit, Jacinto Título: Indigenous leprosy in the armadillo Dasypus novemcinctus ..- Fonte: s.l; s.n; dec. 1978. 3 p. . Resumo: The publication of the unusual. Descritores: XENARTROS/imunol IMUNIDADE NATURAL HANSENIASE/imunol - MEXICO  ESTADOS UNIDOS Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1

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Id: 17759 Autor: Convit, Jacinto Título: Indigenous leprosy in the armadillo Dasypus novemcinctus ..- Fonte: s.l; s.n; dec. 1978. 3 p. . Resumo: The publication of the unusual. Descritores: XENARTROS/imunol IMUNIDADE NATURAL HANSENIASE/imunol - MEXICO  ESTADOS UNIDOS Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1

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Id: 17758 Autor: Convit, Jacinto Título: Indigenous leprosy in the armadillo Dasypus novemcinctus ..- Fonte: s.l; s.n; dec. 1978. 3 p. . Resumo: The publication of the unusual. Descritores: XENARTROS/imunol IMUNIDADE NATURAL HANSENIASE/imunol - MEXICO  ESTADOS UNIDOS Limites: ANIMAL Meio Eletrônico: - . Localização: BR191.1

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Id: 15483 Autor: Skamene, Emil; Schurr, Erwin; Gros, Philippe Título: Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections ..- Fonte: s.l; s.n; 1998. 13 p. . Descritores: ALELOS ANTITUBERCULOSOS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS PROTEINAS DE TRANSPORTE SURTOS DE DOENÇAS SUSCETIBILIDADE A DOENÇA GENOMA BACTERIANO GENOMA HUMANO GENOMA DE PROTOZOARIO LEISHMANIOSE LEISHMANIOSE IMUNIDADE NATURAL LEPROSTATICOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE LIGAÇAO (GENÉTICA) MACROFAGOS PROTEINAS DA MEMBRANA CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS INFECÇOES POR SALMONELLA INFECÇOES POR SALMONELLA TUBERCULOSE TUBERCULOSE TUBERCULOSE TUBERCULOSE Predisposição Genética para Doença Limites: ESTUDO COMPARATIVO ANIMAL Localização: BR191.1; 08338/s

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Id: 15469 Autor: Buu, N; Sánchez, F; Schurr, E Título: The Bcg host-resistance gene ..- Fonte: s.l; s.n; 2000. 5 p. graf. Descritores: VACINA BCG NEOPLASIAS DA BEXIGA NEOPLASIAS DA BEXIGA NEOPLASIAS DA BEXIGA PROTEINAS DE TRANSPORTE PROTEINAS DE TRANSPORTE MARCADORES GENÉTICOS IMUNIDADE NATURAL HANSENIASE HANSENIASE LIGAÇAO (GENÉTICA) PROTEINAS DA MEMBRANA PROTEINAS DA MEMBRANA CAMUNDONGOS TUBERCULOSE PULMONAR TUBERCULOSE PULMONAR PREDISPOSICAO GENETICA PARA DOENCA Limites: ANIMAL Localização: BR191.1; 08324/s

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Id: 15043 Autor: Ulrichs, T; Porcelli, S. A Título: CD1 proteins: targets of T cell recognition in innate and adaptive immunity ..- Fonte: s.l; s.n; 2000. 17 p. ilus, tab. Descritores: FORMAÇAO DE ANTICORPOS APRESENTAÇAO DO ANTIGENO ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS CD1 ANTIGENOS CD1 ANTIGENOS CD1 ANTIGENOS CD1 EVOLUÇAO MOLECULAR GLICOLIPIDIOS GLICOLIPIDIOS IMUNIDADE NATURAL CÉLULAS KILLER NATURAIS HANSENIASE LIPIDIOS LIPIDIOS COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE MAMIFEROS MAMIFEROS CAMUNDONGOS MODELOS MOLECULARES MYCOBACTERIUM MYCOBACTERIUM CONFORMAÇAO PROTÉICA ESTRUTURA TERCIARIA DE PROTEINA RATOS RECEPTORES PARA ANTIGENOS DE CÉLULAS T GAMA-DELTA ESPECIFICIDADE DE ESPÉCIES SUB-POPULAÇOES DE LINFOCITOS T TUBERCULOSE Isoformas de Proteínas/CH/CL/GE/IM Limites: ANIMAL Localização: BR191.1; 07486/s

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Id: 14359 Autor: Levin, Michael; Newport, Melanie Título: Understanding the genetic basis of susceptibility to mycobacterial infection ..- Fonte: s.l; s.n; 1999. 5 p. . Descritores: CRIANÇA GAMBIA IMUNIDADE NATURAL HANSENIASE MALTA CAMUNDONGOS MICOBACTERIOSE RECEPTORES DE INTERFERON TUBERCULOSE PREDISPOSICAO GENETICA PARA DOENCA/*GE Localização: BR191.1; 07474/s

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Id: 14160 Autor: Garred, P; Harboe, M; Oettinger, T; Koch, C; Svegaard, A Título: Dual role of mannan-binding protein in infections: another case of heterosis? ..- Fonte: s.l; s.n; 1994. 7 p. ilus, graf. Descritores: CANDIDA ALBICANS PROTEINAS DE TRANSPORTE PROTEINAS DE TRANSPORTE PROTEINAS DE TRANSPORTE VIGOR HIBRIDO IMUNIDADE NATURAL HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS Localização: BR191.1; 07074/s

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Id: 14072 Autor: Blackwell, Jenefer M Título: Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil ..- Fonte: s.l; s.n; 1998. 8 p. ilus. Descritores: HANSENIASE HANSENIASE LEISHMANIOSE LEISHMANIOSE IMUNIDADE NATURAL LIGAÇAO (GENÉTICA) FENOTIPO TUBERCULOSE TUBERCULOSE Localização: BR191.1; 07133/s

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